000			05424cam a22005654a 4500
001			14207733
003			OSt
005			20250710131829.0
008			051216s2006 nyua b 001 0 eng
010			_a 2005036791
016	7		_a101263798 _2DNLM
020			_a0849327792 _qalk. paper
020			_a9780849327797
035			_a14207733
035			_a(OCoLC)62736887
040			_aDNLM/DLC _cDLC _dNLM _dBAKER _dC#P _dYDXCP _dOCLCQ _dMUQ _dDLC
042			_apcc
050	0	0	_aRM301.25.S55 2006
060	0	0	_a2006 K-070
060	1	0	_aQV 744 _bP9645 2006
082	0	0	_a615/.19 _222
245	0	4	_aThe process of new drug discovery and development / _cedited by Charles G. Smith, James T. O'Donnell.
250			_a2nd ed.
260			_aNew York : _bInforma Healthcare, _cc2006.
300			_a668 p. : _bill. ; _c27 cm.
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
500			_aRev. ed. of: The process of new drug discovery and development / Charles G. Smith. c1992.
504			_aIncludes bibliographical references and index.
505	0		_aOverview of the current process of new drug discovery and development / Charles G. Smith and James T. O'Donnell -- Integrated drug product development: from lead candidate selection to life-cycle management / Madhu Pudipeddi, Abu T.M. Serajuddin, and Daniel Mufson -- The impact of combinatorial chemistry on drug discovery / Michael H. Rabinowitz and Nigel Shankley -- High-throughput screening: enabling and influencing the process of drug discovery / Carol Ann Homon and Richard M. Nelson -- Pharmacological and pharmaceutical profiling: new trends / Joanne Bowes ... [et al.] -- Cell-based analysis of drug response using moving optical gradient fields / Jeff M. Hall ... [et al.].
505	0		_aPatient-derived primary cells in high-throughput differential antitumor screens: let the patients be the guide / Irwin A. Braude -- The evolving role of the caco-2 cell model to estimate intestinal absorption potential and elucidate transport mechanisms / Jibin Li and Ismael J. Hidalgo --
505	0		_aThe promise of metabonomics in drug discovery / Harold J. Kwalwasser and Pauline Gee -- Pharmacogenetics and pharmacogenomics in drug development and regulatory decision-making: report of the first FDA-PWG-PhRMA-druSafe workshop / Lawrence J. Lesko ... [et al.] -- Drugs from molecular targets for CNS and neurodegenerative diseases / William T. Comer and Gönül Veliçelebi -- Safety pharmacology / Jean-Pierre Valentin and Tim G. Hammond -- Nonclinical drug safety assessment / Frederick E. Reno -- Preclinical genotoxicity testing: past, present and future / Richard H.C. San -- The need for animals in biomedical research / Charles G. Smith -- Defining the actual research approach to the new drug substance / Charles G. Smith -- Pharmacokinetics: pharmacodynamics in new drug development / Sarfaraz K. Niazi --
505	0		_aPharmaceutics and compounding issues in new drug development and marketing / Loyd V. Allen -- Late stage and process development activities / Charles G. Smith -- Contract research organizations: role and function in new drug development / F. Richard Nichol -- The front lines of clinical research: the industry / Lori Nesbitt -- Horizons for cancer chemotherapy (and nonchemotherapy) / Daniel D. Von Hoff -- Human immunodeficiency virus/acquired immune deficiency syndrome: clinical testing challenges / Vincent Idemyor -- Common technical document: the changing face of the new drug application / Justina A. Molzon -- Electronic publishing / Heather L. Wallace -- The important role of pharmacists in a complex risk-management system: managing the risks from medical product use by focusing on patient education, monitoring, and adverse event reporting / Justina A. Molzon -- Liability, litigation, and lessons in new drug development / James T. O'Donnell -- Problems in the nondrug marketplace / Stephen Barrett -- Patents and new product development in the pharmaceutical and biotechnology industries / Henry Grabowski --
505	0		_aThe pharmaceutical revolution: drug discovery and development / John C. Somberg -- The discovery of Rituxan / Mitchell E. Reff -- Funding the birth of a drug: lessons from the sell side / Howard E. Greene -- Innovations for the drug development pathway: what is needed now / Janet Woodcock -- Managing R & D uncertainty and maximizing the commercial potential of pharmaceutical compounds using the dynamic modeling framework / Mark Paich ... [et al.].
650		0	_aDrugs _xResearch _xHistory.
650		0	_aDrugs _xDesign _xHistory.
650	1	2	_aDrug Design.
650	2	2	_aDrug Evaluation, Preclinical.
650	2	2	_aDrug Evaluation.
700	1		_aSmith, Charles G. _q(Charles Giles)
700	1		_aO'Donnell, James, _cPharm. D.
700	1		_aSmith, Charles G. _q(Charles Giles) _tProcess of new drug discovery and development.
856	4	1	_3Table of contents _uhttp://www.loc.gov/catdir/toc/ecip065/2005036791.html
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0647/2005036791-d.html
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2lcc _cBK _n0
999			_c3365 _d3365